Oleanolic Acid plant extract

Oleanolic acid is a naturally occurring , widely distributed in food and medicinal plants, related to . It can be found in (American pokeweed), and spp, garlic, etc. It is relatively non-toxic, antitumor, and , as well as exhibiting antiviral properties. Oleanolic acid was found to exhibit strong anti- activity, the related compound betulinic acid was used to create the first commercial drug. It was first studied and isolated from several plants, including (leaves), (leaves and twigs), (whole plant), (leaves), (whole plant), and (aerial part). Other Syzygium species including java apple () and rose apples contain it. An extremely potent synthetic triterpenoid analogue of oleanolic acid was found in 2005, that are powerful inhibitors of cellular inflammatory processes. They work by the induction by of (iNOS) and of in mouse . They are extremely potent inducers of the (e.g., elevation of and ), which is a major protector of cells against and stress.